The role of hepatitis B and C in causing hepatocellular carcinoma has been made clear in the last 20–30 years by clinical, basic, and epidemiological studies. Recent research has also explored the prevention of hepatocellular carcinoma through the control of chronic hepatitis B or C viral infection. This review volume covers in detail the various aspects of hepatitis viruses in relation to hepatocellular carcinoma, ranging from the epidemiology of the disease to its prevention and treatment. Readers will thus gain a complete, well-informed knowledge of this increasingly prevalent disease.