B. Alan Wallace points out the many assumptions required to adopt the realist view, and the nihilism implicit in the instrumentalist position. He then proposes a radical philosophical alternative based upon the Buddhist Centrist view. Avoiding the pitfalls of both realism and instrumentalism, as well as materialism and idealism, this perspective focuses on the participatory nature of scientific observation and theorizing. All phenomena are seen as dependently related events lending themselves to multiple interpretations, providing us with the freedom and responsibility to choose our reality within the context of valid experience. The concluding chaptors of this provocative work explore the implications of this view for understanding the nature of the mind and its relation to the body.