In the early 18th century, Edinburgh was a filthy backwater town synonymous with poverty and disease. Yet by century's end, it had become the marvel of modern Europe, home to the finest minds of the day and their breathtaking innovations in architecture, politics, science, the arts, and economies – all of which continues to echo loudly today. Adam Smith penned <I>The Wealth of Nations</I>. James Boswell produced <I>The Life of Samuel Johnson</I>. Alongside them, pioneers such as David Hume, Robert Burns, James Hutton, and Sir Walter Scott transformed the way we understand our perceptions and feelings, sickness and health, relations between the sexes, the natural world, and the purpose of existence.