Cross-over trials are an important class of design used in the pharmaceutical industry and medical research, and their use continues to grow. Cross-over Trials in Clinical Research, Second Edition has been fully updated to include the latest methodology used in the design and analysis of cross-over trials. It includes more background material, greater coverage of important statistical techniques, including Bayesian methods, and discussion of analysis using a number of statistical software packages.<br>* Comprehensive coverage of the design and analysis of cross-over trials.<br><br>* Each technique is carefully explained and the mathematics is kept to a minimum.<br><br>* Features many real and original examples, taken from the author's vast experience.<br><br>* Includes discussion of analysis using SAS, S-Plus and, GenStat, StatXact and Excel.<br><br>* Written in a style suitable for statisticians and physicians alike.<p>* Computer programs to accompany the examples in the book can be downloaded from the Web<p><br>Primarily aimed at statisticians and researchers working in the pharmaceutical industry, the book will also appeal to physicians involved in clinical research and students of medical statistics.