<DIV><P>This primary textbook for a first course in pharmacology offers an integrated, systems-based, and mechanism-based approach to understanding drug therapy. Each chapter focuses on a target organ system, begins with a clinical case, and incorporates cell biology, biochemistry, physiology, and pathophysiology to explain how and why different drug classes are effective for diseases in that organ system.</P> <p>Over 400 two-color illustrations show molecular, cellular, biochemical, and pathophysiologic processes underlying diseases and depict targets of drug therapy. Each Second Edition chapter includes a drug summary table presenting mechanism, clinical applications, adverse effects, contraindications, and therapeutic considerations. New chapters explain how drugs produce adverse effects and describe the life cycle of drug development.</P> <p>The fully searchable online text and an image bank are available on thePoint.</P></DIV>