The discovery of the family of ligands and receptors, also known as BAFF, transformed the understanding of B-lymphocyte selection, survival, activation, and homeostasis. Laboratory and clinical researchers in immunology, pathology, and related disciplines share some of the new insights. Among them are the BAFF receptor regulation of peripheral B-lymphocyte survival and development, the role of BAFF and APRIL in antibody production and diversification, TACI signaling and its role in immunity, systemic immune-based rheumatic diseases, translating BAFF inhibition from the mouse to non-human primates and humans, and the role of BLyS in B-cell malignancies. Annotation ©2010 Book News, Inc., Portland, OR (booknews.com)