While the title may only refer to cell apoptosis and cell senescence in the treatment of cancer, the 28 papers presented by the editors (all of the Massey Cancer Center, Virginia Commonwealth U.) actually examine a range of cell death pathways beyond apoptosis, such as mitotic catastrophe and autophagy and different modes of cell growth arrest and their connections to different treatment modalities. The papers are organized into six sections discussing apoptosis and alternative modes of cell death; telomeres and telomerase, senescence, genomic instability, and tumorigenesis; DNA damage response, signaling pathways, and tumorigenesis; resistance and sensitization; established cancer therapies; and recent and developing cancer therapies. Annotation ©2008 Book News, Inc., Portland, OR (booknews.com)