This is the first volume of a two-volume work describing methods from across the interdisciplinary subject of bioinformatics, or the management and analysis of data for the life sciences. Keith (School of Mathematical Sciences, Queensland U. of Technology, Australia) has devoted the volume to coverage of data and databases, sequence analysis, and phylogenetics and evolution. Individual topics addressed by the volume's 24 chapters include managing sequence data, RNA structure determination by nuclear magnetic resonance, protein structure determination by x-ray crystallography, pre-processing of microarray data and analysis, genome annotation, multiple sequence alignment, finding genes in genome sequence, bioinformatics detection of alternative splicing, reconstruction of full-length isoforms from splice graphs, sequence segmentation discovering sequence motifs, modeling sequence evolution, inferring trees, detecting the presence and location of selection in proteins, phylogenetic model evaluation, inferring ancestral gene order, genome rearrangement by the double cut and join operation, inferring ancestral protein interaction networks, computational tools for the analysis of rearrangements in mammalian genomes, detecting the lateral genetic transfer, detecting genetic recombination, inferring patterns of migration, and fixed-parameter algorithms in phylogenetics. Annotation ©2008 Book News, Inc., Portland, OR (booknews.com)