This book constitutes the thoroughly refereed post-workshop proceedings of the first AIME 2007 workshop From Knowledge to Global Care, K4CARE 2007, held in Amsterdam, The Netherlands, in July 2007, in conjunction with the 11th International Conference on Artificial Intelligence in Medicine, AIME 2007.The 10 revised full papers presented together with 2 invited papers were carefully selected during a second round of reviewing and improvement from 14 lectures given at the workshop and are presented in extended version in the book. The papers are organized in topical sections on health care knowledge management, health care knowledge elicitation, health care knowledge transformation, and health care intelligent systems.