This book constitutes the refereed proceedings of the 10th International Conference on Distributed Computing and Networking, ICDCN 2009, held in Hyderabad, India, during January 3-6, 2009.<BR>The 20 papers and 32 short presentations presented together with 3 keynote talks and a memorial lecture on A.K. Choudhury were carefully reviewed and selected from 179 submissions. The topics addressed are sensor networks, multi-core and shared memory, peer-to-peer-computing, reliability and security, distributed computing, network algorithms, fault tolerance and models, fault tolerance and replication, wireless networks, and grid and cluster computing.