Since his mother's death, Carter Kane has been traveling the globe with his father, Egyptologist Julius Kane. His sister, Sadie, has been living with their grandparents in London. On Christmas Eve, Sadie and Carter are reunited when their father brings them to the British Museum. Carter and Sadie watch as Julius summons a mysterious figure, who quickly banishes their father. Carter and Sadie discover that the gods of Ancient Egypt are waking. To save their father, they embark on a dangerous journey and learn about their family's links to the House of Life, a secret order that has existed since the time of the pharaohs.