While the study of the role of chemokine receptors in physiology and pathology is fairly new, according Harrison (pharmacology and therapeutics, U. of Florida College of Medicine) and Lukacs (pathology and immunology, U. of Michigan Medical School), it is clear that they dwarf their fellow G-protein coupled receptors in terms of the total number of receptors and their functional diversity. They present 18 papers that are collectively intended to distill information regarding the molecular and cell biology, physiology, and pathology of chemokines and their receptors in a single volume. Specific topics addressed include the birth and maturation of chemokines and their receptors; structural biology of chemokines and their receptors; chemokines signaling in T-lymphocyte migration; chemokines and chemokine receptors and neutrophil, dendritic cell, lymphocyte, hematopoietic stem cell, and progenitor cell trafficking; chomkines in transplantation biology; the role of the chemokine system in arthritis, atherosclerosis, allergic lung disease, HIV/AIDS, fibrosis, angiogenesis, cancer, and neuroinflammation; and pharmaceutical targeting of chemokine receptors. Annotation ©2008 Book News, Inc., Portland, OR (booknews.com)