This issue of Perioperative Nursing Clinics, Guest Edited by George Allen, features subject topics such as: OR Attire's Potential for Infection Transmission; Strategies for Preventing Sharps Injuries; Managing Patients with MDROs - Implementing Isolation Procedures in the Perioperative Setting; Anesthesia Care Providers - Identifying/Mitigating Potential for Infection Transmission; Urinary Catheter Insertion and Care in the Perioperative Setting; Hand Hygiene and the Surgical Team; Outlining Effective Strategies for Preventing SSI; Environmental Sanitation - Review of New Technologies; Reprocessing Instruments: Focus on Eye Surgery and TASS (Toxic Anterior Segment Syndrome); Skin Prepping to Maximize Positive Outcomes; Improving the process of supplying instruments from central processing to the OR using the LEAN method; Using Performance Improvement Methodology in Finding the Cause of Increase Biological Cultures in the Operating Room and Solutions for Corrections.