In “Prairie Guns” homesteaders have taken up land on the plains of Colorado that were formerly free range. Cattle baron Colton Miller and his hired gun riders hate the homesteaders, especially Buff Brady and Luther Hart, two former cowboys who hope eventually to throw their quarter-sections together to form a cattle ranch, but are viewed as traitors by the cattlemen. When the daughter of a murdered homesteader offers to sell her small herd of cattle to Brady and Hart, they can only afford to buy it on a term basis over three years. But in this Miller sees his chance to frame the two for rustling and swears out warrants against them. Once they are arrested and jailed, their buildings are dynamited. What Miller doesn’t expect is the ferocity with which the two will fight back to hold on to the land that is lawfully theirs.