In 14 chapters, education and educational psychology specialists from the US explain the use of single-case intervention research in psychology and education and related fields. They describe the rationale and components of single-case design; the methodological advantages of incorporating randomization; visual and nonoverlap analysis in single-case design; permutation and randomization statistical tests; a statistical software program for conducting randomization tests using Microsoft Excel; multilevel models for analyzing data; analyses using hierarchical models as a framework; and the role of single-case designs in supporting intervention development and evaluation at the Institute of Education sciences. The final section consists of discussion from contributors who have used single-case design in their research and school psychology journal editors who have published this research. Annotation ©2014 Ringgold, Inc., Portland, OR (protoview.com)